Embryotoxicity of Fluconazole on Developing Chick Embryos

Sadia Bashir1, Yashal Fatima1, Muhammad Khalil Ahmad Khan1

1Department of Zoology, University of Okara,56300, Okara, Punjab, Pakistan

E-mail: yashalfatima16@gmail.com

Fluconazole is commonly first generation triazole. It is anti fungal and used for the treatment of fungal
infections that disturb your skin hair and nails. The present study was tested on chick embryo in order to check the
embryotoxicity and teratological effect of fluconazole in them. Fertilized eggs were taken and divided into 4 groups.
Two groups were experimental groups and treated with different concentration of fluconazole. One group was
treated with distilled water while fourth group was untreated and named as control group. Dose was given on 4th day of incubation while recovery was made on 9thday.

There were different anomalies observed in them like
hydrocephaly , microcephaly shorting of beak , agenesis , Amelia , micromelia , anophthalmia , microphthalmia ,
and kyphosis .There were also observed the Morphometric measurments with the difference of significant
(p<0.001) & (p<0.01) in CR length , body weight , head circumference , Eye circumference , Forelimb and
HindLimb. Different vital organ defects were also observed in histological studies. It concludes that the Fluconazole
in various combinations has been found to cause embryotoxicity and teratological consequences in chick embryos.

Keywords: Amelia, Hydrocephaly, Teratogenicity, Anomalies, Anti-fungal agents

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